PT - JOURNAL ARTICLE AU - Ritter, C. AU - Dangl, J. L. TI - Interference between Two Specific Pathogen Recognition Events Mediated by Distinct Plant Disease Resistance Genes. AID - 10.1105/tpc.8.2.251 DP - 1996 Feb 01 TA - The Plant Cell PG - 251--257 VI - 8 IP - 2 4099 - http://www.plantcell.org/content/8/2/251.short 4100 - http://www.plantcell.org/content/8/2/251.full SO - Plant Cell1996 Feb 01; 8 AB - We demonstrate that the interaction of the avirulence gene avrRpt2 and the cognate resistance gene RPS2 interferes with the interaction of avrRpm1-RPM1 in Arabidopsis. Interference is mediated outside of the bacterial pathogen Pseudomonas syringae, presumably at the level of recognition of avr-dependent signals, yet does not require the wild-type RPS2 product. A numerical excess of P. syringae expressing avrRpm1 can overcome this interference in mixed inoculations. The interference of avrRpt2-RPS2 engagement with RPM1-dependent functions is mirrored by transcriptional activation of genes preferentially expressed during RPM1- or RPS2-mediated disease resistance reactions. This demonstration of interference between two plant disease resistance genes suggests that their products compete for a common element(s) in a signal transduction pathway leading to disease resistance.