PT  - JOURNAL ARTICLE
AU  - Rate, Debra N.
AU  - Cuenca, James V.
AU  - Bowman, Grant R.
AU  - Guttman, David S.
AU  - Greenberg, Jean T.
TI  - The Gain-of-Function Arabidopsis <em>acd6</em> Mutant Reveals Novel Regulation and Function of the Salicylic Acid Signaling Pathway in Controlling Cell Death, Defenses, and Cell Growth
AID  - 10.1105/tpc.11.9.1695
DP  - 1999 Sep 01
TA  - The Plant Cell
PG  - 1695--1708
VI  - 11
IP  - 9
4099  - http://www.plantcell.org/content/11/9/1695.short
4100  - http://www.plantcell.org/content/11/9/1695.full
SO  - Plant Cell1999 Sep 01; 11
AB  - We isolated a dominant gain-of-function Arabidopsis mutant, accelerated cell death 6 (acd6), with elevated defenses, patches of dead and enlarged cells, reduced stature, and increased resistance to Pseudomonas syringae. The acd6-conferred phenotypes are suppressed by removing a key signaling molecule, salicylic acid (SA), by using the nahG transgene, which encodes SA hydroxylase. This suppression includes phenotypes that are not induced by application of SA to wild-type plants, indicating that SA acts with a second signal to cause many acd6-conferred phenotypes. acd6–nahG plants show hyperactivation of all acd6-conferred phenotypes after treatment with a synthetic inducer of the SA pathway, benzo(1,2,3)thiadiazole-7-carbothioic acid (BTH), suggesting that SA acts with and also modulates the levels and/or activity of the second defense signal. acd6 acts partially through a NONEXPRESSOR OF PR 1 (NPR1) gene–independent pathway that activates defenses and confers resistance to P. syringae. Surprisingly, BTH-treated acd6–nahG plants develop many tumor-like abnormal growths, indicating a possible role for SA in modulating cell growth.